Advantages of freeze dryers
There are various methods of drying, such as sun-drying, cooking, drying, spray-drying, and vacuum-drying. However, ordinary drying methods are usually performed at a temperature of 0 ° C or higher.
Dried products generally have problems of shrinking in size and hardening the texture. Most of the volatile components will be lost. Some heat-sensitive substances will be denatured and inactivated, and some substances will even be oxidized. Therefore, compared with the product before drying, the properties of the product after drying are very different. The freeze-drying principle is basically carried out below 0 ° C, that is, in a frozen state of the product. Only when the residual moisture content of the product is reduced in the later period, the product is allowed to rise to a temperature above 0 ° C, but generally does not exceed 40 ° C. Under vacuum conditions, when the water vapor directly sublimes out, the drug remains in the ice shelf when it freezes, forming a sponge-like loose porous structure, so its volume is almost unchanged after drying. Just add water for injection before reuse and it will dissolve immediately.
优势 The advantages of freeze dryer:
1, many heat-sensitive substances will not denature or inactivate;
2. When drying at low temperature, the loss of some volatile components in the substance is small;
3. During the freeze-drying process, the growth of microorganisms and the role of enzymes cannot be performed, so the original properties can be maintained;
4. Because it is dried in a frozen state, the volume is almost unchanged, the original structure is maintained, and no concentration occurs;
5. Because the water in the material exists in the form of ice crystals after pre-freezing, the inorganic salt-soluble substances that were originally dissolved in water are evenly distributed among the materials;
6. The dried material is loose and porous, showing a sponge-like shape. After adding water, it dissolves quickly and completely, and the original properties are restored almost immediately;
7. Since drying is performed under vacuum, there is very little oxygen, so some easily oxidizable substances are protected.
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